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DMXE is an extremely novel chemical, so use the utmost caution during your experiments.

What is DMXE?

DMXE is a dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It was believed to have been first synthesised by a laboratory in the Netherlands in 2020. Little is known about DMXE due to its relative novelty, so we will provide information about the chemical class it belongs to – arylcyclohexylamines.

We also have a article titled as DMXE: The Ultimate Guide, that’s well worth reading.

Chemical Properties of DMXE

DMXE is an arylcyclohexylamine dissociative. An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamino or ethylamino, or tertiary cycloalkylamines such as piperidino and pyrrolidino, are the most commonly encountered N-substituents.

Pharmacological effects of DMXE

Initial reports suggest that DMXE shares many subjective properties with MXE. More-so than other chemicals such as MXPr, MXiPr and DCK.

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as ketamine, PCE and methoxetamine (3-MeO-2′-Oxo-PCE). While no scientific studies have been conducted to verify this, structure-activity relationship analysis suggests that 2′-Oxo-PCE likely exhibits its observed effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.

NMDA receptors (a subtype of receptors for glutamate, which are the principal excitatory neurotransmitters in the nervous system) allow for electrical signals to pass between nerve cells in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists have been shown to disrupt this signaling by blocking these receptors. This disconnection of information flow in the nervous system leads to loss of sensation (anesthesia), difficulty moving (motor discoordination), and eventually this substance’s equivalent of the “K-hole”.

Some of the most commonly reported effects are:

• Stimulation
• Perception of bodily lightness
• Physical autonomy
• Physical euphoria
• Dissociation
• Enhanced proprioception

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Product Name: DMXE Hydrochloride 40mg Pellets
Other Name(s): Deoxymethoxetamine, 3D-MXE, methetamine, 3-Me-2′-oxo-PCE Hydrochloride
IUPAC Name: 2-(ethylamino)-2-(3-methylphenyl)-cyclohexanone hydrochloride
Molar Mass: 267.8 g/mol

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How to Buy DMXE Pellets

You can buy DMXE Pellets and other research chemicals here at CelsiusZero. All of our chemicals are third party lab tested. If you wish to see HNMR results for DMXE Pellets or any other chemical, just email us at

Responsible Research with DMXE Pellets

Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on DMXE Pellets, so does The Third Wave. Never conduct research with a chemical without learning about it first.

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DMXE Pellets and all other products are strictly for research purposes only and not for human consumption.

Store DMXE Pellets in a cool, dry place away from sunlight.

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DMXE Pellets stock last updated at: December 2024

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